I take it you mean for a neck-through cbg type guitar, if so, ignoring the need for a truss rod etc, and just factoring the pick up area, you need to remove enough wood to fit the p/up, which will greatly reduce the neck strength, quite a few ways around this, but a simple method is to just add extra wooden members each side of the current neck, or a single piece under the neck to compensate for any reduction in strength. Personally i would screw and glue the added pieces for comfort of mind
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I take it you mean for a neck-through cbg type guitar, if so, ignoring the need for a truss rod etc, and just factoring the pick up area, you need to remove enough wood to fit the p/up, which will greatly reduce the neck strength, quite a few ways around this, but a simple method is to just add extra wooden members each side of the current neck, or a single piece under the neck to compensate for any reduction in strength. Personally i would screw and glue the added pieces for comfort of mind